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Honors Thesis Archive

Author Heepke Wendroth
Title The aging-related gene expression of a component of Sp100-rs in adipocytes may correlate to the redistribution of white adipocyte tissue to various organs in Mus musculus
Department Biochemistry/Molecular Biology & Biology
Advisors Margaret Goodman, Kristin Cline, and Michelle McWhorter
Year 2013
Honors University Honors
Full Text View Thesis (714 KB) Note: This is a very large file; it may be easier to download the file to your computer and open it from there.
Abstract The component of an Sp100-rs (Csprs) gene has shown an aging-related increase in expression in mouse tissues, including the heart, kidney, and fats. While the up-regulation is not always significant, the trend of increased expression suggests that Csprs may be used as a biomarker for aging. Csprs seems to be associated primarily with adipose tissue, and its expression usually correlates to high amounts of adiponectin. Furthermore, within white adipose tissue, Csprs is mostly expressed in adipocytes but not in stromal vascular cells, suggesting that the gene may, in fact, be adipose-specific. Therefore, the aging-related increase of Csprs in tissues like the heart and kidney could be related to the fat accumulation in these tissues with age. This suggests a link between Csprs expression, aging, and development of various aging-related diseases such as diabetes and coronary heart disease.

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